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Apigenin Supplement

Apigenin Supplement

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Apigenin is a powerful plant-derived bioflavonoid found in chamomile, parsley, and a range of herbs. It has been used by humans for centuries, in their quest to live longer, healthier lives.

At Naturecan, we’ve harnessed the best of nature in one convenient supplement, combined with science-backed formulas to bring you a vegan-friendly, high-strength Apigenin supplement.

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Key Benefits

  • May support healthy ageing and longevity*
  • Contributes to your everyday wellness routine
  • Derived from natural parsley herb extract

Product Overview

  • Vegan and plant-based formula
  • 100mg of Apigenin per capsule
  • 60 servings per bottle (2-month supply)
  • Traditionally used in calming teas
  • Third-party tested for purity and potency

Apigenin is a naturally occurring flavonoid gaining popularity in the wellness world for its potential health benefits, particularly in promoting a calm and relaxed state, and contributing towards healthy ageing. 

Traditionally consumed through herbs like chamomile and parsley, dietary intake of apigenin can be inconsistent and low in concentration, which is why many turn to supplements to gain its full benefits.

Each of our Apigenin capsules contains 500mg of parsley herb extract, with 100mg of pure Apigenin, providing a high bioavailable daily dose to meet your intake needs. With a clean, plant-based formula that slots into any diet or wellness routine with ease, this supplement offers an effective way to support your overall health goals.

Dosage Instructions

Take 1 capsule daily with food and water.

We suggest taking your capsule 30–60 minutes before bedtime. Do not exceed the recommended daily dose unless advised by a healthcare professional.

Ingredients

Parsley Herb Extract, Glazing Agent (Capsule (Hydroxypropyl Methylcellulose)).

Nutritional Information

Nutrient

Per Capsule

Parsley Herb Extract

500mg

– of which Apigenin

100mg


Certainty of Purity

At Naturecan, quality is the backbone of everything we do. Our Apigenin supplement is crafted with high-grade parsley extract, a sustainable source of natural apigenin. Each ingredient is third-party tested to ensure purity, safety, and effectiveness.

  • Science-backed ingredients
  • All-natural and plant-based
  • Made in Europe in GMP-certified facilities
  • Sustainable sourcing and production
  • Full transparency on sourcing and formulation

Our commitment to clean, effective supplements guarantees you know exactly what you're putting in your body, with no hidden fillers or nasties.

Ingredients Explained

Every ingredient has a role. Backed by research, blended with purpose – nothing unnecessary.

Apigenin is found in fruits and vegetables, but parsley leaf extract stands out as one of the richest and most reliable natural sources. Our extract contains a standard 20% apigenin content, guaranteeing a consistent and effective dose in every capsule.

Supplementation offers a reliable, concentrated form of apigenin that can be measured and integrated easily into your wellness regime, which solves the inconsistencies in apigenin levels through diet alone.

The Hidden Toll of Poor Sleep: Why Is Quality Sleep Key To A Healthy Lifestyle?

Just a short period of poor-quality sleep can disrupt your entire body and mind in surprising ways. While the odd restless night is manageable, consistent poor sleep over 1–3 months can start to unravel your health — and fast.

Mental & Emotional Impact

  • Week 1–2: You may feel foggy, irritable, and more emotional than usual.
  • Week 3–4: Anxiety levels can increase, and the ability to cope with stress declines.
  • Month 2–3: You’re at higher risk for depression, burnout, and emotional dysregulation.

Physical Health Consequences

  • Week 1–2: Blood sugar levels and blood pressure begin to creep up.
  • Week 3–4: Immune function weakens, increasing vulnerability to illness.
  • Month 2–3: Chronic inflammation sets in, raising the risk of heart disease, weight gain, and hormonal imbalance.

Metabolism & Hormones

  • Within weeks: Ghrelin (the hunger hormone) rises while leptin (which tells you you’re full) drops, leading to cravings and overeating.
  • After 1–2 months: Metabolism slows, fat storage increases, and testosterone or oestrogen levels may dip.

Sleep is the foundation of energy, mood, focus, recovery, and longevity. When it crumbles, so does your resilience. That’s why prioritising high-quality sleep can help protect your mind, body, and overall  wellbeing.

References

  1. Kramer DJ, Johnson AA. Apigenin: a natural molecule at the intersection of sleep and aging. Front Nutr. 2024 Feb. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC10929570/
  2. Allemailem KS, Almatroudi A, Alharbi HOA, AlSuhaymi N, Alsugoor MH, Aldakheel FM, Khan AA, Rahmani AH. Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11202028/
  3. Ogura Y, Kitada M, Xu J, Monno I, Koya D. CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats. Aging. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7343471/

Additional Information Icon

Legal status: Apigenin Supplement is sold in the United States in accordance with applicable dietary supplement regulations under the Food and Drug Administration (FDA) and DSHEA."
Active ingredient: Apigenin (from parsley herb extract)
Maximum intake: 50 mg daily
Adults
How it works: Apigenin is a plant flavonoid that supports cellular signalling pathways associated with antioxidant and anti-inflammatory activity.
Scientific name: Apigenin
Non-scientific name: Apigenin
Recommended intake: mg daily
Adults
Safety: Do not exceed the recommended daily intake. Food supplements should not be used as a substitute for a varied, balanced diet and healthy lifestyle. If you are pregnant, breastfeeding, taking medication or have a medical condition, consult a healthcare professional before use. Keep out of reach of children.
Used by: Adults
Gtin: 5060961526686
Study: Apigenin: a natural molecule at the intersection of sleep and aging
Study url: https://pmc.ncbi.nlm.nih.gov/articles/PMC10929570/
Study subject: Apigenin impact on sleep and aging
Study design: Narrative Review
Study description: Insights from this peer-reviewed review position apigenin as a unique natural molecule that intersects sleep and aging by inhibiting the NAD+-consuming enzyme CD38, which effectively raises NAD+ levels and modulates pathways associated with neuroprotection, anxiety relief, and enhanced sleep quality.
Study: Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment
Study url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11202028/
Study subject: Role of Apigenin in Disease Prevention and Treatment
Study design: Narrative Review
Study description: As detailed in this peer-reviewed review, apigenin serves as a potent antioxidant and anti-inflammatory bioflavonoid that modulates multiple signaling pathways to provide protective effects against cancer, diabetes, and cardiovascular diseases while enhancing the efficacy of traditional chemotherapeutic agents.
Study: CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats
Study url: https://pmc.ncbi.nlm.nih.gov/articles/PMC7343471/
Study subject: The therapeutic potential of Apigenin on Diabetic Kidney Disease (DKD)
Study design: Preclinical Study
Study description: Evidence from this peer-reviewed study demonstrates that apigenin acts as a CD38 inhibitor to restore the intracellular NAD+/NADH ratio and Sirt3 activity, effectively reducing mitochondrial oxidative stress and renal tubular injury in diabetic rats.
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